Symbol
Name
ID

Cyld
CYLD lysine 63 deubiquitinase
MGI:1921506

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Abnormal bleeding
Disease(s) Associated with CYLD	Abnormal bleeding
Brooke-Spiegler syndrome

Mouse Phenotypes

thymus hyperplasia

enlarged spleen

abnormal B cell differentiation

abnormal class switch recombination

decreased immature B cell number

increased pro-B cell number

increased double-positive T cell number

decreased B-1 B cell number

increased follicular B cell number

increased marginal zone B cell number

increased B cell number

abnormal T cell number

decreased CD4-positive, alpha-beta T cell number

decreased CD8-positive, alpha-beta T cell number

abnormal B cell morphology

abnormal mature B cell morphology

abnormal spleen morphology

abnormal spleen marginal zone morphology

abnormal B cell physiology

increased IgA level

increased IgG1 level

increased IgG2a level

increased IgG2b level

decreased IgG3 level

decreased IgM level

Availability

Mouse Genotype

Cyld^tm1.1Awai/Cyld^tm1.1Awai

Cyld^tm1Lex/Cyld^tm1Lex

Cyld^tm1Scs/Cyld^tm1Scs

Cyld^tm1Awai/Cyld^tm1Awai
Tg(CD19-cre/ERT2)1Cgn/? (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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